(一)个人基本情况
杜冠魁,男,汉族,群众,出生于1983年6月,浙江省永康市人,生物化学与分子生物学专业博士,教授职称,研究领域为糖尿病治疗机制,现就职于365英国上市网站官网基础医学与生命科学学院。
(二)教育背景:
2004.09-2010.01 浙江大学 生物化学与分子生物学(直接攻博)
2000.09-2004.07 浙江大学 生物技术
(三)所获荣誉
2020年入选海南省南海青年名家
2020年入选海南省高层次人才“拔尖人才”
2019年入选海南省“515人才工程”第三层次
(四)教学与科研成果
1、主持的项目
[1] 国家自然科学基金:(81960672)益智仁有效成分重塑肠道菌群治疗2型糖尿病的作用机制(2019年获资助)
[2] 国家自然科学基金:(81641010)血浆和红细胞microRNA 表达谱及其与蚕豆病的相关性研究(2016年获资助)
[3] 海南省自然科学基金(821RC561):基于肠道菌群-炎症因子轴探讨槟榔干预抑郁症的作用机制(2021年获资助)
[4] 海南省教育厅基金:(HNKY2014-51)G6PD 活性与 II 型糖尿病肾病的相关性研究(2014年获资助)
2、代表性论文/专著、参编教材等
[1] 《生物化学》(2019年)书号:ISBN 978-7-5608-8378-6,副主编
[2] 《生物化学与分子生物学实验教程》(2014年)书号:ISBN 978-7-308-11583-4,参编
[3] 《生物化学与分子生物学实验》(2014年)书号:ISBN 978-7-5609-,参编
公开出版的专著、发表论文
1、专著
[1]《microRNA 研究与糖尿病综合治疗概述》.肖曼,杜冠魁著. 长春:吉林大学出 版社,2017.07,230 千字,书号为 ISBN 978-7-5692-0825-2.
2、发表的科研论文
SCI论文
[1] Jiang C, Cui Z, Fan P, Du G. Effects of dog ownership on the gut microbiota of elderly owners. PloS one. 2022;17(12):e0278105. (通讯作者, SCI,3.752)
[2] Chen. G, Ou. J, Liu. J, Liao. H, Ding. L, Fan. P, et al. Acute Thrombocytopenia Induced by Trastuzumab Due to Complement Reaction: A Case Report. Frontier in medicine. 2022;9. (通讯作者, SCI,5.058 )
[3] Cui Z, Li J, Zhen Y, Fan P, Du G. The Effect Of Whole Grain Diet On The Gut Microbiota Of The Elderly. Frontiers in Nutrition.2022; 9:919838 (通讯作者, SCI, 6.576 )
[4] Yang Y, Huang H, Cui Z, Chu J, Du G. UPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut. Drug Des Devel Ther. 2021;15:4827-4836(通讯作者,SCI,4.26)
[5] Ying L, Yang Y, Zhou J, Huang H, Du G. Effect of chewing betel nut on the gut microbiota of Hainanese. PloS one 2021; 16:e0258489. (通讯作者,SCI,3.24)
[6] Ying L, Wang D, Du G. Analysis of Bioactive Components in the Fruit, Roots, and Leaves of Alpinia oxyphylla by UPLC-MS/MS. Evidence-Based Complementary and Alternative Medicine 2021; 2021:5592518. (通讯作者,SCI,2.629)
[7] Wang A, Chen B, Jian S, Cai W, Xiao M, Du G. miR-206-G6PD axis regulates lipogenesis and cell growth in hepatocellular carcinoma cell. Anticancer Drugs 2021; 32:508-16. (通讯作者,SCI,2.248)
[8] Du G, Huang H, Zhu Q, Ying L. Effects of cat ownership on the gut microbiota of owners. PloS one 2021; 16:e0253133. (第一作者和通讯作者,SCI,3.24)
[9] Du G, Xiao M, Chen B, Wang A, Zhu Q, Cai W. Metabolic profiling reveals alterations in the erythrocyte response to fava bean ingestion in G6PD-deficient mice. Journal of the science of food and agriculture 2021; 101:1562-71. (第一作者和通讯作者,SCI,3.638)
[10] Zhu Q, Jiang S, Du G. Effects of exercise frequency on the gut microbiota in elderly individuals. MicrobiologyOpen 2020; 9:e1053. (通讯作者,SCI,3.142)
[11] Jiang S, Zhu Q, Mai M, Yang W, Du G. Vitamin B and vitamin D as modulators of gut microbiota in overweight individuals. International journal of food sciences and nutrition 2020:1-9. (通讯作者,SCI,3.483)
[12] Du G, Xiao M, Zhu Q, Zhou C, Wang A, Cai W. Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice. Biological research 2019; 52:9. (第一作者和通讯作者,SCI,2.482)
[13] Xiao M, Ying L, Li S, Fu X, Du G. Progress on research and development of Paederia scandens as a natural medicine. Int J Clin Exp Med 2019; 12:158-67. (通讯作者,SCI,0.166)
[14] Du G, Xiao M, Yu S, Wang M, Xie Y, Sang S. Phyllanthus urinaria: a potential phytopharmacological source of natural medicine. Int J Clin Exp Med 2018; 11:6509-20.(第一作者,SCI,0.181)
[15] Du G, Xiao M, Wei X, Zhou C, Li S, Cai W. Hepatic transcriptional profiling response to fava bean-induced oxidative stress in glucose-6-phosphate dehydrogenase-deficient mice. Gene 2018. (第一作者,SCI,2.638)
[16] Xiao M, Fu X, Ni Y, Chen J, Jian S, Wang L, Li L, Du G. Protective effects of Paederia scandens extract on rheumatoid arthritis mouse model by modulating gut microbiota. J Ethnopharmacol 2018; 226:97-104. (通讯作者,SCI,3.414)
[17] Xie Y, Xiao M, Ni Y, Jiang S, Feng G, Sang S, Du G. Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota. J Diabetes Res 2018; 2018:4230590. (通讯作者,SCI,3.04)
[18] Du G, Xiao M, Zhang X, Wen M, Pang C, Jiang S, Sang S, Xie Y. Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney. Biological research 2017; 50:9.(第一作者,SCI,2.357)
[19] Sang S, Xiao M, Ni Y, Feng G, Xiong X, Luo Z, Du G, Xie Y. Alpinia oxyphylla Miq. extract changes microRNA expression profiles in db-/db-mouse livers. Int J Clin Exp Med 2017; 10:14447-57. (共同通讯作者,SCI,0.833)
[20] Pang C, Huang G, Luo K, Dong Y, He F, Du G, Xiao M, Cai W. miR-206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9. Cancer Med 2017; 6:2398-409. (共同通讯作者,SCI,3.202)
[21] Xie Y, Xiao M, Li D, Liu H, Yun F, Wei Y, Sang S, Du G. Anti-diabetic effect of Alpinia oxyphylla extract on 57BL/KsJ db-/db- mice. Exp Ther Med 2017; 13:1321-8. (通讯作者,SCI,1.410)
[22] Li S, Chen R, Luo K, Guo Y, Xiao M, Du G. Areca nut extract protects against ovariectomy-induced osteoporosis in mice. Exp Ther Med 2017; 13:2893-9. (通讯作者,SCI,1.410)
[23] Xiao M, Du G, Zhong G, Yan D, Zeng H, Cai W. Gas Chromatography/Mass Spectrometry-Based Metabolomic Profiling Reveals Alterations in Mouse Plasma and Liver in Response to Fava Beans. PloS one 2016; 11:e0151103. (共同第一作者,SCI,2.806)
[24] Wang X, Du G, Wang X, Meng Y, Li Y, Wu P, Yi K. The function of LPR1 is controlled by an element in the promoter and is independent of SUMO E3 ligase SIZ1 in response to low Pi stress in Arabidopsis thaliana. Plant and cell physiology 2010; 51:380-94. (共同第一作者,SCI,3.929)
专利
[1] 具有抗炎作用的鸡矢藤-葫芦茶组合物及其制备方法和应用。授予日起2021-02-23,专利号:ZL 2017 1 0453388.4。权利人:肖曼;杜冠魁;符小鹏;蔡望伟等。(第二排序) 学术经历及社会服务
1、工作经历
2020.01-至今 365英国上市网站官网 教师 教授
2015.01-2019.12 365英国上市网站官网 教师 副教授
2010.01-2014.12 365英国上市网站官网 教师 讲师
2、学术团体兼职情况
2018.05-至今 中国老年学和老年医学学会抗衰老分会委员
2022.05-至今 海南省免疫学会分子免疫与转化医学分会副主委