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邹卫国，二级研究员，博士生导师。国家杰出青年科学基金获得者、入选国家高层次人才计划（青年类）。长期致力于运动医学与骨生物学基础研究，通过综合运用生物化学、分子生物学、动物模型等多种研究手段，建立体内、体外高通量筛选系统，研究间充质干细胞增殖与分化的分子机制以及多种相关疾病的致病机理，并通过分子遗传学手段建立了骨骼早衰、力学感知失调、关键干细胞稳态失调等多种动物模型，模拟骨质疏松、骨关节炎、骨折等常见骨科疾病，阐明其中关键机制。受邀担任Bone Research、Bone等杂志编委，兼任ICMRS BOD Member-at-large、中国生物工程学会转化医学专业委员会副主任委员、中华医学会骨科学分会组织工程与再生医学青年组组长，中国骨质疏松与骨矿盐疾病分会基础组常委、中国老年医学会骨质疏松分会创新与转化专委会常委等。
v 个人经历
2024.03 - 至今，海南医科大学，副校长
2020.03 - 至今，中国科学院分子细胞科学卓越创新中心，研究员，研究组长，博士生导师
2012.08 - 2020.03，中国科学院上海生命科学研究院生物化学与细胞生物学研究所，研究员，研究组长，博士生导师
2009.09 - 2012.08，哈佛大学，公共卫生学院，Yerby fellow
2007.03 - 2009.08，哈佛大学，公共卫生学院，Research Fellow
2003.09 - 2007.02，美国Scripps研究所，Research Associate
1998.09 - 2003.07，中国科学院上海生命科学研究院生物化学与细胞生物学研究所，生物化学与分子生物学，理学博士
1994.09 - 1998.07，南开大学，生物化学，理学学士
v 获奖情况
2017年，国家自然科学基金国家杰出青年科学基金
2013年，国家自然科学基金优秀青年科学基金
2013年，国家高层次人才计划（青年类）
团队主要从事间充质干细胞/运动系统功能性前体细胞、骨发育与重建及相关疾病机制的研究。研究方向包括间充质干细胞是一种多能干细胞，可以分化为成骨细胞、软骨细胞、脂肪细胞、肌肉细胞等。运动系统功能性干细胞包括膜内成骨的骨膜干细胞、软骨内成骨的骨干细胞、关节软骨干细胞、肌腱干细胞、肌肉干细胞等。间充质干细胞/运动系统功能性干细胞向不同组织细胞的分化受到多种遗传因素和表观遗传因素的影响，并受多种信号途径调控。调控因素的异常将导致多种疾病，包括先天性发育畸形、运动系统退行性疾病如骨质疏松症、骨性关节炎以及肌腱疾病等。
邹卫国团队迄今发表论文80余篇，以第一作者或通讯作者身份在Nat Cell Biol.、Mol Cell.、Dev Cell.、J Clin Invest. (2011, 2019, 2020)、Nat Commun. (2016, 2017, 2020, 2022)、Sci Adv. (2020a, 2020b)、Adv Sci. (2022 Cover Story, 2024)、J Exp Med.、Cell Res. 等杂志发表了一系列研究成果。
v 代表性论著
1. Yiming Liu#, Xinyu Tang#, Hui Shu#, Weiguo Zou*, Bo Zhou*. Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood. Developmental Cell. 2024, 59(9): 1192-1209.
2. Zengxin Jiang#, Guobin Qi#, Xuecheng He, Yifan Yu, Yuting Cao, Changqing Zhang*, Weiguo Zou*, Hengfeng Yuan*. Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis. Advanced Science. 2024, 11(12): e2307388.
3. Rui Shao#, Jinlong Suo#, Zhong Zhang#, Mingxiang Kong, Yiyang Ma, Yang Wen, Mengxue Liu, Lenan Zhuang, Kai Ge, Qing Bi, Changqing Zhang*, Weiguo Zou*. H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis. Cell Death and Differentiation. 2024, 31(1): 106-118.
4. Ruici Yang#, Dandan Cao#, Jinlong Suo, Lingli Zhang, Chunyang Mo, Miaomiao Wang, Ningning Niu, Rui Yue*, Weiguo Zou*. Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation. Bone Research. 2023, 11(1): 35.
5. Jinlong Suo#, Rui Shao#, Ruici Yang, Jinghui Wang, Zhong Zhang, Duo Wang, Ningning Niu*, Xianyou Zheng*, Weiguo Zou*. Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation. Cell Death and Disease. 2023, 14: 336.
6. Heng Feng, Bo Jiang, Wenhui Xing, Jun Sun, Matthew B. Greenblatt, Weiguo Zou*. Skeletal Stem Cells: Origins, definitions, and functions in bone development and disease. Life Medicine. 2022, 1(3): 276-293.
7. Lijun Wang#, Xiuling You#, Dengfeng Ruan#, Rui Shao, Hai-Qiang Dai, Weiliang Shen, Guo-Liang Xu, Wanlu Liu*, Weiguo Zou*. TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. 2022, 13: 4709.
8. Bo Gao#, Bo Jiang#, Wenhui Xing, Zaiqi Xie, Zhuojing Luo*, Weiguo Zou*. Discovery and application of postnatal nucleus pulposus progenitors essential for intervertebral disc homeostasis and degeneration. Advanced Science. 2022, 9(13): e2104888. Cover Story
9. Jinlong Suo#, Sihai Zou#, Jinghui Wang#, Yujiao Han, Lingli Zhang, Chenchen Lv, Bo Jiang, Qian Ren, Long Chen, Lele Yang, Ping Ji, Xianyou Zheng*, Ping Hu*, Weiguo Zou*. The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Research. 2022, 10(1): 31.
10. Lijun Wang, Xiuling You, Lingli Zhang, Changqing Zhang, Weiguo Zou*. Mechanical regulation of bone remodeling. Bone Research. 2022, 10(1): 16.
11. Rui Shao#, Zhong Zhang#, Zhan Xu, Huiling Ouyang, Lijun Wang, Hongwei Ouyang, Matthew Greenblatt, Xi Chen, Weiguo Zou*. H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Research. 2021, 9(1): 30.
12. Heng Feng#, Wenhui Xing#, Yujiao Han#, Jun Sun, Mingxiang Kong, Bo Gao, Yang Yang, Zi Yin, Xiao Chen, Yun Zhao, Qing Bi, Weiguo Zou*. Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. Journal of Clinical Investigation. 2020, 130(12): 6354-6365.
13. Jun Sun#, Heng Feng#, Wenhui Xing, Yujiao Han, Jinlong Suo, Alisha R. Yallowitz, Niandong Qian, Yujiang Shi, Matthew B. Greenblatt, Weiguo Zou*. Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Science Advances. 2020, 6(45): eaaz1410.
14. Jinlong Suo#, Xue Feng#, Jiayi Li, Jinghui Wang, Zuoyun Wang*, Lei Zhang*, Weiguo Zou*. VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances. 2020, 6(43): eaba4147.
15. Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo Zou*. Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature Communications. 2020, 11(1): 282.
16. Meizhu Bai#, Yujiao Han#, Yuxuan Wu, Jiaoyang Liao, Lin Li, Lijun Wang, Qing Li, Wenhui Xing, Luonan Chen, Weiguo Zou*, Jinsong Li*. Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biology. 2019, 17(7): e3000350.
17. Yujiao Han, Heng Feng, Jun Sun, Xiaoting Liang, Zhuo Wang, Wenhui Xing, Qinggang Dai, Yang Yang, Anjia Han, Zhanying Wei, Qing Bi, Hongbin Ji, Tiebang Kang*, Weiguo Zou*. Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation. Journal of Clinical Investigation. 2019, 129(5): 1895-1909.
18. Lijun Wang#, Ningning Niu#, Li Li#, Rui Shao, Huiling Ouyang, Weiguo Zou*. H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biology. 2018, 16(11): e2006522.
19. Yujiao Han, Xiuling You, Wenhui Xing, Zhong Zhang, Weiguo Zou*. Paracrine and endocrine actions of bone - the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. 2018, 6: 16.
20. Jun Sun#, Joerg Ermann, Ningning Niu, Guang Yan, Yang Yang, Yujiang Shi, Weiguo Zou*. Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. 2018, 6: 14.
21. Qinggang Dai#, Zhan Xu, Xuhui Ma, Ningning Niu, Siru Zhou, Furong Xie, Lingyong Jiang, Jun Wang*, Weiguo Zou*. mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death Differentiation. 2017, 24(11): 1886-1899.
22. Zhan Xu, Matthew B. Greenblatt, Guang Yan, Heng Feng, Jun Sun, Sutada Lotinun, Nicholas Brady, Roland Baron, Laurie H. Glimcher, Weiguo Zou*. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 2017, 8: 14570.
23. Ningning Niu, Jian-Feng Xiang, Qin Yang, Lijun Wang, Zhanying Wei, Ling-Ling Chen, Li Yang, Weiguo Zou*. RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell Discovery. 2017, 3: 16050.
24. Rui Shao#, Jia Liu#, Guang Yan, Jinfang Zhang, Yujiao Han, Jianfeng Guo, Zhan Xu, Zhu Yuan, Jiankang Liu, Marcos Malumbres, Lixin Wan*, Wenyi Wei*, Weiguo Zou*. Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell Research. 2016, 26: 699-712.
25. Zhen Liu, Xiao Yao, Guang Yan, Yichi Xu, Jun Yan, Weiguo Zou*, Gang Wang*. Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nature Communications. 2016, 7: 11149.
26. Weiguo Zou*, Matthew B. Greenblatt, Nicholas Brady, Sutada Lotinun, Bo Zhai, Heather de Rivera, Anju Singh, Jun Sun, Steven P. Gygi, Roland Baron, Laurie H. Glimcher, Dallas C. Jones. The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. Journal of Experimental Medicine. 2013, 210(9): 1793-1806.
27. Weiguo Zou, Xi Chen, Jae Shim, Zhiwei Huang, Nicholas Brady, Dorothy Hu, Rebecca Drapp, Kirsten Sigrist, Laurie H. Glimcher, Dallas Jones*. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nature Cell Biology. 2011, 13(1): 59-65.
28. Lixin Wan#, Weiguo Zou#, Daming Gao, Hiroyuki Inuzuka, Hidefumi Fukushima, Anders H. Berg, Rebecca Drapp, Shavali Shaik, Dorothy Hu, Chantel Lester, Manuel Eguren, Marcos Malumbres, Laurie H. Glimcher, Wenyi Wei*. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Molecular Cell. 2011, 44(5): 721-733.
29. Weiguo Zou#, Matthew B. Greenblatt#, Jae-Hyuck Shim, Shashi Kant, Bo Zhai, Sutada Lotinun, Nicholas Brady, Dorothy Zhang Hu, Steven P. Gygi, Roland Baron, Roger J. Davis, Dallas Jones, Laurie H. Glimcher*. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. Journal of Clinical Investigation. 2011, 121(11): 4383-4392.
v 成果转化
1. 邹卫国，冯恒，邢文晖，韩玉娇；Hedgehog信号通路抑制剂在制备治疗异位骨化产品中的用途，申请号202011493287.8
2. 邹卫国，王丽君，尤修玲，张玲莉；抑制破骨细胞活性及治疗骨质疏松的试剂及其应用，申请号201911128528.6
3. 邹卫国，牛宁宁，邵瑞，颜广；基于col2a1启动子的eGFP表达载体构建及在转基因斑马鱼中的应用，申请号201611021808.3
4. 邹卫国，罗春霞，邱松波，张紫莱，孙兰英，顾锦法，裴子飞，刘新垣；一种抗癌靶向基因病毒药物的制备方法，专利号ZL02157662.9
邹卫国团队承担国家重点基础研究发展计划（973计划）课题，国家自然科学基金委重大项目课题、重点项目，中国科学院战略性先导科技专项课题等。
v 项目列表
1. 中国科学院战略性先导科技专项（B类），XDB0570402，RNA折叠与适配体技术升级，2023/10-2028/09
2. 国家自然科学基金重点项目，82230082，PIEZOs蛋白介导髓核力学稳态抑制椎间盘退变的分子机制研究，2023/01-2027/12
3. 国家重点研发计划“发育编程及其代谢调节”重点专项，2022YFA0806600，主要环境污染物对个体发育和代谢的影响及关键机制研究，2022/12-2027/11
4. 中国科学院稳定支持基础研究领域青年团队计划，YSBR-077，复杂性状与重大疾病解析，2022/07-2027/07
5. 国家自然科学基金重大项目，81991512，骨源性因子对骨骼自身及骨外器官/系统稳态维持的作用和机制，2020/01-2024/12
6. 国家自然科学基金杰出青年科学基金，81725010，骨发育与重建及相关疾病的机制，2018/01-2022/12
7. 国家自然科学基金面上项目，81672119，组蛋白甲基转移酶NSD1调节软骨发育与骨关节炎的分子机制研究，2017/01-2020/12
8. 中国科学院战略性先导科技专项（B类），XDB19030102，骨骼损伤条件下细胞可塑性调控，2016/06-2021/05
9. 国家重点基础研究发展计划（973计划），2015CB964503，化学诱导重编程及转分化的平台技术研究，2015/01-2019/08
10. 国家重点基础研究发展计划（973计划），2014CB964704，多能干细胞分化所得中胚层细胞的功能鉴定，2014/01-2019/06
11. 国家自然科学基金面上项目，31371463，泛素连接酶Smurf2调节骨的发育与骨质疏松的分子机制研究，2014/01-2017/12
12. 国家自然科学基金优秀青年科学基金，81322027，骨发育以及相关疾病的分子基础，2014/01-2016/12
13. 国家海外高层次人才计划（青年类），骨的衰老与发育及相关疾病机制，2013/07‐2016/06
